2-4 Dichloropyrimidine |Cas N0: 3934-20-1 | India | Manufacturer from mallalieu james's blog

Introduction

 

2,4-Dichloropyrimidineis a significant compound in organic chemistry, notable for its role as a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. In this detailed guide, we will explore its chemical structure, properties, applications, safety considerations, and more.

 

Chemical Structure and Properties

 

2,4-Dichloropyrimidine(cas no-3934-20-1), with the chemical formula C4H2Cl2N2, is a chlorinated derivative of the heterocyclic compound pyrimidine. Its structure consists of a pyrimidine ring (a six-membered aromatic ring containing two nitrogen atoms at positions 1 and 3) with chlorine atoms substituted at the 2 and 4 positions. This compound's chemical structure imparts unique properties that make it valuable in organic synthesis.

 

Physical Properties

 

At room temperature, 2,4-dichloropyrimidine appears as a white to pale yellow crystalline solid. It has a molecular weight of approximately 148.98 grams per mole. The compound's melting point typically falls within the range of 68-72°C (154-162°F), and its boiling point is approximately 211-212°C (412-414°F) at atmospheric pressure.

 

Solubility

 

2,4-Dichloropyrimidine is sparingly soluble in water but exhibits better solubility in various organic solvents, including polar solvents like acetone, ethanol, and dimethyl sulfoxide (DMSO).Its solubility characteristics contribute to its utility in organic synthesis reactions, where it often serves as a reagent or intermediate.

 

Chemical Properties

 

This compound's chemical properties stem from its pyrimidine ring structure and the presence of chlorine substituents. It can undergo various transformations, including nucleophilic substitution reactions, condensation reactions, and cyclization reactions. These reactions enable the synthesis of a wide range of functionalized pyrimidine derivatives.

 

Applications

 

2,4-Dichloropyrimidine finds widespread application in organic synthesis as a key intermediate for the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It serves as a building block in the synthesis of pyrimidine-based drugs, herbicides, fungicides, and insecticides. Its versatility and functional group compatibility make it a valuable tool for chemists across different industries.

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Safety and Handling

 

As with handling any chemical compound, proper safety precautions must be observed when working with 2,4-dichloropyrimidine. It is important to use appropriate personal protective equipment, including gloves, safety goggles, and lab coats, to minimize exposure. Additionally, the compound should be handled in a well-ventilated area to avoid inhalation of vapors or dust particles.

 

Conclusion

 

In conclusion, 2,4-dichloropyrimidine plays a vital role in organic synthesis, serving as a versatile building block for the preparation of various pharmaceuticals, agrochemicals, and specialty chemicals. Its unique chemical structure and properties make it a valuable tool for chemists seeking to create novel compounds for diverse applications.

 

FAQs

 

1. What are some common reactions involving 2,4-dichloropyrimidine?

   Common reactions include nucleophilic substitution, condensation, and cyclization reactions. These reactions enable the synthesis of functionalized pyrimidine derivatives with diverse applications.

 

2. Is 2,4-dichloropyrimidine toxic?

   While 2,4-dichloropyrimidine is not highly toxic, it should be handled with care to minimize exposure. Proper safety precautions should be followed, including the use of appropriate personal protective equipment and working in a well-ventilated area.

 

3. What are the primary uses of 2,4-dichloropyrimidine?

   2,4-Dichloropyrimidine is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It serves as a key building block for the preparation of pyrimidine-based drugs, herbicides, fungicides, and insecticides.